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DNA-encoding to improve performance and allow parallel evaluation of the binding characteristics of multiple antibodies in a surface-bound immunoassay format

by Adam Washburn | May 1, 2011 | Scientific Publications

Abstract High affinity capture agents against protein targets are essential components for immunoassays, regardless of specific analysis format. Here, we describe the use of DNA-encoded antibodies for rapidly screening the kinetic and equilibrium binding properties of...

Multiplexed inkjet functionalization of silicon photonic biosensors

by James Kirk | Apr 7, 2011 | 2011 News, Publications, Scientific Publications

Abstract The transformative potential of silicon photonics for chip-scale biosensing is limited primarily by the inability to selectively functionalize and exploit the extraordinary density of integrated optical devices on this platform. Silicon biosensors, such as...

Silicon photonic microring resonator arrays for scalable and multiplexable bioanalysis

by SPIE - Matthew Luchansky | Feb 8, 2011 | Scientific Publications

Read more: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/7888/1/Silicon-photonic-microring-resonator-arrays-for-scalable-and-multiplexable-bioanalysis/10.1117/12.880492.full?SSO=1

Characterization of the evanescent field profile and bound mass sensitivity of a label-free silicon photonic microring resonator biosensing platform

by Matthew Luchansky | Dec 15, 2010 | Scientific Publications

Abstract Silicon photonic microring resonators have emerged as a sensitive and highly multiplexed platform for real-time biomolecule detection. Herein, we profile the evanescent decay of device sensitivity towards molecular binding as a function of distance from the...

Multiplexed Evaluation of Capture Agent Binding Kinetics Using Arrays of Silicon Photonic Microring Resonators

by Ji-Yeon Byeon | Nov 18, 2010 | 2010 News, Publications, Scientific Publications

Abstract High affinity capture agents recognizing biomolecular targets are essential to the performance of many proteomic detection methods. Herein, we report the application of a label-free silicon photonic biomolecular analysis platform for simultaneously...

Photonics-on-a-chip: recent advances in integrated waveguides as enabling detection elements for real-world, lab-on-a-chip biosensing applications

by Adam Washburn | Oct 18, 2010 | Scientific Publications

Abstract By leveraging advances in semiconductor microfabrication technologies, chip-integrated optical biosensors are poised to make an impact as scalable and multiplexable bioanalytical measurement tools for lab-on-a-chip applications. In particular, waveguide-based...
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